كليدواژه :
پزشكي , سيروز كبدي , كارآزمايي باليني , كبد , Liv-52 , LIV25 , Cirrhosis , داروهاي گياهي , Herbal medicine , Clinical trial
چكيده لاتين :
Introduction: Cirrhosis is the irreversible sequel of various disorders that damage liver cells permanently over time. Presently, the use of herbal medicines for prevention and control of chronic liver diseases is in the focus of attention for both the physicians and the patients; the reasons for such shift toward the use of herbals include the expensive cost of conventional drugs, adverse drug reactions, and their inefficacy. In the present study, the aim was to find out the efficacy of herbal medicine Liv-52 (consisting of Mandur basma, Tamarix gallica and herbal extracts of Capparis spinosa, Cichorium intybus, Solanum nigrum, Terminalia arjuna and Achillea millefolium) on liver cirrhosis.
Methodology: The outcome measures included child-pugh score, ascitis, serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), total billirubin, albumin, prothrombin time, platelet and white blood cells counts. The indices were recorded in all patients before and after 6 months of drug or placebo treatment.
Results: The results demonstrated that the patients treated with Liv-52 for 6 months had significantly better child-pugh score, decreased ascitis, decreased serum AST and ALT. In placebo administered patients all the clinical parameters recorded before and after 6 months were not significantly different.
Discussion Conclusion: We conclude that Liv-52 possesses hepatoprotective effect in cirrhotic patients. This protective effect of Liv-52 can be attributed to the diuretic, anti-inflammatory, antioxidative, and immunomodulating properties of the component herbs.
