بررسي ارتباط علايم آزمايشگاهي و باليني بانماي هيستولوژيك در بيماران باسندرم نفروتيك

To Determine the Correlation of the Histological Picture of Rental Biopsy Specimens with Clinical Signs in Cases of Nephritic Syndrome

Introduction: To determine correlation of the histological picture of renal biopsy specimens with clinical signs in cases of nephrotic and nephritic syndrome who needed renal biopsy, we designed this study. Methods: All biopsies together with clinical features of patients were evaluated once more. Place of study was Imam Khomeini Hospital in Tehran from first month of 1380 to end of 1381. Results: The commonest diagnosis was membranous nephropathy (32%). One hundred cases were included. Forty percent of patients were male.28% of patients were older than 40 years. Hypertension had significant correlation with glomerular sclerosis, high creatinine level and massive proteinuria (p-4.001, p=0.066). Frequency of hypertension and high creatinine in the admission time were highest in focal and segmental glomerulonephritis (p=0.001). Membranous glomerulopathy and minimal change had the mildest presentation. Conclusion: Hypertension and high creatinine in the admission time which had significant correlation with renal insufficiency and glomerular sclerosis needs emergent workup and treatment in order to prevent End Stage Renal Disease.