در نوزادان مبتلا به هيپرروبينمي GGPD بررسي ضرورت تعيين فعاليت آنزيم گلوكز-6- فسفات دهيدروژناز

Evaluation the Indication of Measurement Activity of Glucose-6- Phosphate Dehydrogenase Deficiency (G6PD) in Admitted Jaundiced Newborns

Jaundice is one of the symptoms of G6PD deficiency. The physicians who are caring for jaundiced and healthy neonates always wonder whether they should perform measurement activity of G6PD in these babies or not? This study was done over 33 months by 2000 infants with jaundice that admitted to two University Hospitals. 89 of 2000 jaundiced newborn had G6PD deficiency. Thus the incidence was 4.45%. The male/female ratio was 10.1. Mean minimal Hb Concentration and mean Reticolcyte in two groups were similar. Thus there wasnʹt hemolysis in patients with G6PD deficiency. In conclusion G6PD deficiency should be considered in the differential diagnosis of icter in spite of normal concentration and recommended measurement in admitted jaundiced newborn for diagnosis of etiology of icter and exchange transfusion prophylaxis of favism.