در بيماران ديابتي نوع دو B و آپوليپوپروتيين A1 و آنتي اكسيدان ها بر سطوح سرمي آپوليپوپروتيين B بررسي تاثير برخي از ويتامين هاي گروه

THE IMPACT OF B-GROUP VITAMINS AND ANTIOXIDANTS ON SERUM LEVELS OF APOLIPOPROTEIN Al AND B IN TYPE 2 DIABETES

Background: Lipoprotein abnormalities have been identified among the several risk factors that could account for increases the risk of CVD in diabetes. Abnormal status of B-group and antioxidant vitamins in diabetes may illustrate the benefits of these vitamins supplementation on modification of lipid profiles. Methods: As a randomized double blind placebo controlled clinical trial, 110 type 2 diabetic patients were randomly assigned to one of the five treatment groups and received one of the following supplements per day for a period of 2 months: 1) B-group vitamins including B2 (10 mg), B6 (10mg), B12 (200µg) and Folate (1000µg); 2) B-group vitamins and vitamin E (100mg); 3) B-group vitamins and vitamin C (200mg); 4) B-group vitamins, vitamins E (100mg) and C (200mg) and 5) placebo. Fasting blood samples at the beginning and at the end of 2 months trial were collected and analyzed for cholesterol, triglyceride, apolipoproteins Al and B (apo Al & B), vitamin E, folate, vitamin B12 in serum and vitamin C in whole blood. Differences in baselines models. Covariates and changes in variables during study were adjusted by analysis of covariance using general linear. Results: No significant changes were found in mean serum apolipoproteins levels after 2 months of supplementation. Vitamin E variation showed significant positive correlation with variation in apo AI (P=0.003) and apo B (P<0.001). In multiple regression analysis, serum vitamin E levels were an independent and important predictor of serum apoAl and B levels (P=0.002 and P<0.001, respectively). Serum vitamin B12 variation was important predictor of serum apo B levels (P<0.05). Conclusion: Serum vitamin E level is a good predictor of serum apo Al and B levels. Further increases in dose of vitamin supplements and intervention period are recommended for obtaining the desirable modifications.