كليدواژه :
عصب واگ , آلومينيوم , Gastric acid secretion , تحريك الكتريكي , Aluminium , Rat , پزشكي , ترشح اسيد معده , موش صحرايي , vagus nerve
چكيده لاتين :
For many years, aluminium - containing antacids have been used. According to basic role of calcium in gastric acid secretion , and inhibitory effect of aluminium on voltage - dependent calcium channels, this study were designed . Vagal stimulation was used for gastric acid induction in this experiment. For this purpose, after anesthesia (nesdonal, 60 mg/kg) and gastric cannulation , cervical vagotomy was performed in rats . Also , heart rate was recorded before and after vagotomy. After bilateral vagotomy , peripheral end of vagus nerves (left or right) stimulated with 12V, 4Hz and 1 msec width current for 15 min, . Gastric secretory response to right or left vagal stimulation do not different significantly. Gastric acid output was measured with wash out method in 15-min intervals during stimulation period until return to basal acid level. Aluminium (10 or 50 pg/kg) injected from tail vein, 2 min before second time of stimulation, and acid output was measured in a ,same time. Statisical analysis was performed by paired Hest.
In first group (10,µg/kg Al,n=8) vagal stimulation increased acid output significantly (from 3.5±0.12 to 35.2±2.3µmol/15 min , P<0.000/) and aluminium injection has no significant effect . In second group (50 µg/kg Al, n=8) gastric acid secretion was inhibited with aluminium significantly (P<0.001). Therefore , it seems that inhibitory effect of aluminium on acid secretion is dose-dependent. In addition to buffering ofʹ aluminium,il has an inhibitory effect on gastric acid secretion. in rat.
