بررسي تاثير گلوكز آمين بر روي فرآيندهاي انحلال ، اتصال پروتييني و ضريب توزيع ايبوپروفن

Evaluating the effect of glucosamine on dissolution, protein binding and partition coefficient of ibuprofen

OBJECTIVES: Ibuprofen was th‘ first non-steroidal anti-inflammatory drug (NSAID) which was commonly used for the treatment of pain and inflammation. Ibuprofen can cause serious gastrointestinal, renal and cardiovascular side effects especially when used in high doses and/or over long periods of time. NSAIDs have been combined with other drugs. including opioid analgesic agents and glucosamine in order to achieve an effective degree of analgesia with lower dosage of the NSAID. These combination products exhibit a variety of effects on the level of analgesia, which may be sub-additive (inhibitory), additive or super additive (synergistic). Contrastive pharmacological results have been obtained in co-administration of ibuprofen and glucosamine. The reason for these contrastive results is unknown. In this study, we tried to understand the reason of these contradictions. METHODS: For this mean, solubility. dissolution rate, protein binding and partition coefficient of ibuprofen alone and in. combination with glucosamine were studied. RESULTS: The results showed that glucosamine increased solubility and dissolution rate of ibuprofen. In preparations with 1:1 or higher ratios of ibuprofen to glucosarnine, the protein binding of ibuprofen was increased The peak of melting point was altered in DSC thermogram that can indicate to formation of complex between ibuprofen and glucosamine during process. Partition coefficient of drug decreased in combination form with glucosamine. This is an important phenomenon in permeability of drug through mucus membrane. CONCLUSION: The Above results may be helpful to explain the contrastive results that obtained from studies.