بر كاهش ليپوفوشين كليه در رتهاي ديابتيك E بررسي اثردرماني ويتامين

A Study on the effect of Vitamin £ on the reduction of Renal Lipofuscin in Diabetic Rats

Since diabetes is a progressive disease, therefore early diagnosis is impatant in prevention of the metabolic changes associated with diabetes is a high expression of lipofuscin in erythrocytes and specially renal proximal tubular cells. This change leads to the renal toxicity, nephropathy, and provides functional disorders in kidneys. Some studies suggest that the glycogenosis and the increase in the plasma level of free O2 radicals in the absence of vitamin E cause the changes . on the other hand, Vitamin E deficiency in renal proximal tubules decreases the cell survival. Since vitamin E is a physiological antioxidant and a membrane stabilizer, in this study we treated diabetic rats with vitamin E. For this reason, 30 male whistar rats were divided in to the groups, one control group and two experimental groups (alloxan-induced diabetic rats), (n=10). Experimental group 1 were treated for 8 weeks, With 10 mg/kg of vitamin E daily. After 8 weeks all the rats were anestetized, dissected and their kindyes were fixed by formalin 10% . After fixation, all of specimens processed serially, sectioned and stained with Schmorel, s method. The resuls indicated a significant decrease in lipofuscin level of the experimental group 1 in comparison the group 2. This result indicates that vitamin E may prevent lipofuscin production and provide a renal protection against diabetes.