فرمولاسيون و كنترل قرص لراتادين

Formulation and control of Loratadine Tablet

Loratadine is a potent competitive antagonist of Hj receptors which attaches to the peripheral Hi receptors selectively and also to the Hj receptors of brain with less affinty, therefore there is almost no central nervous system side effects such as sedation. Loratadine tablets is administered one tablet each day in the reliep of the symptoms of allergic seasonal rhinitis and idiopathic chronic urticaria. Different formulations containing l0mg loratadine were prepared using wet and dry granulation methods. In wet granulation, water ,starch paste and aqueous solution of PVP were used as granulating liquid. This study showed that wet granulation method using PVP aqueous solution as binder was the proper method, and the produced tablets had good physicochemical properties which were comparable with claritine.