فرمولاسيون فينا سترايد موضعي و برريس جذب پوستي آن

Formulation of topical finasteride and evaluation of its percutaneous absorption

Topical finasteride formulation is one of the most effective treatments of androgenic or male pattern alopecia. The effectiveness of these formulations strongly depends on the penetration of the drug through scalps skin. In this study, we tried to formulate finasteride topical formulation with suitable percutaneous absorption as well as good appearance, consistency, spreadability, viscosity and stability. For this purpose, 14 formulations were prepared using different solvent systems and investigated in the case of stability and physical characteristics. Three different formulations were selected for percutaneous absorption studies. These studies were done by using standard Franz diffusion cells and reverse phase HPLC method. In the second step, three penetration enhancers (SLS, CTAB and transcutol P) with different percents (0.25, 0.5, 1 and 2 w/v %) were added to the base formulation and the effect of them on the skin absorption of finasteride were studied. The results did not show any skin penetration enhancement SLS and CTAB in all percents whereas; transcutol P enhanced the transdermal absorption of finasteride significantly. Optimum percent for transcutol P was determined 1% (w/v). Trnscutol P with 0.25% concentration also increased percutaneous absorption of the drug in the first sampling time (15min). Inability of SLS and CTAB in enhancement of the drug penetration through the skin probably aroused from drug-enhancer complexation and formation of micelles with low penetration ability containing the drug molecules.