محاسبه محلوليت داروها در مخلوطهاي هيدروالكلي با استفاده از تيوري نظم متحرك

Calculation of Drug Solubility in Hydro-Alcoholic Mixtures Using Mobile Order Theory

Theory of mobile order for explaining the solubility phenomenon was reviewed and the equations for representation of solubility data in mono-solvent and binary solvent systems were discussed. The accuracy of the mobile order (MO) was evaluated using eleven solubility data sets in water-ethanol mixtures and was compared with that of the combined nearly ideal binary solvent / Redlich-Kister (CNIBS/R-K) equation. The mean and standard deviations of the models were 2.70 ± 1.44 and 1.31 ±0.19, respectively for MO and CNIBS/R-K and the mean difference was statistically significant. This suggested that MO is not capable of calculating solute solubility more accurate than models based on classical thermodynamics and farther studies is required to establish MO accuracy.