كليدواژه :
Skin penetration , Myrj , ديكلوفناك , امول ژل , جذب پوستي , افزايش دهنده , Transcutol , سينيول , ترانسكيو تول , علوم دارويي , ميرج , Diclofenac , Emulgel , Penetration enhancer , Cineol , پزشكي
چكيده لاتين :
The purpose of the present study was to prepare diclofenac diethyl amine emulgel with better skin penetration compared to the marketed product in Iran. To achieve such a product, several formulations containing different kinds and amounts of gelling agents, have been prepared. By changing the type and amount of gelling agent, type and ratio of organic phase composition, and solvent amount the best formulation with better stability has been selected. The skin penetration study was carried out using skin penetration study apparatus equipped with Franz cells. The concentration of drug in the receptor phase of Franz cells was determined using UV spectrophotometer and HPLC. To evaluate the effect of type and concentration of skin penetration enhancer agents on the penetration of drug through rat skin, Transcutol, Myrj 52 and Cineol was used with different concentrations. After calculating flux and EF values and comparing the graph of cumulative amount of drug penetrated through the skin, the formulation which had 0.25% Myrj 52 as skin penetration enhancer was selected as the best formulation with higher skin penetration.
