اثر دانه شنبليله بر نشانه هاي زودرس يايسگي

Effect of Fenugreek seed on early menopausal symptoms

Perimenopausal stage is accompanied with symptoms such as: hot flash, anxiety, depression, muscle and joint pain which can disturbe womenʹs life. At present Hormone Replacement Therapy (HRT) is the most common method in treatment of menopausal complications but HRT can increase risk of tumor development in estrogen- sensitive tissues. Phytoestrogens are one of the alternative therapies in HRT. Phytoestrogens are herbal compounds that have estrogenic activity. Fenugreek is one of the herbs that contains phytoestrogen compounds but its effect has not been assessed on early menopausal symptoms yet. This study aimed to investigate the effect of Fenugreek seed on early menopausal symptoms. In this quasi experimental study, 2 groups of perimenopausal women were selected. Each group contained 25 patients. Women in control group received 2 periods consist of 0.625 mg conjugated estrogen and 10 mg medroxy progesterone acetate. Women in Fenugreek group received 6 g fenugreek seed powder in granulated form for 8 weeks. The Greene menopausal scale was used to assess change in early menopausal symptoms at baseline and after 4, 8 weeks of treatment. Statistical analysis was used for comparison between control and fenugreek groups. Greene score between control and Fenugreek groups at baseline was not significantly different (p=0.776). After 4 and 8 weeks of treatment on control group compared to Fenugreek group Greene score showed significant decrease (p<0.001, p<0.001).Greene score within control and Fenugreek groups showed a significant decrease after 4 and 8 weeks (p<0.001, p<0.001). Use of Fenugreek seed for 4 and 8 weeks caused significant reduction of total Green menopausal score but this effect was less than HRT. Further studies using double blind placebo-controlled clinical trial are needed.