و مطالعه باليني مقدماتي PAROTIA PERSICA)DC.( C.A.MEY فرمولاسيون فرآورده ضدعرق از گياه انجيلي

Formulation of herbal antiperspirant from parotia persica (DC.)C.A.Mey. (Hamamelis persica) and preliminary clinical study

parotia persica syn. Hamamelis persica ( Hamamelidaceae) is indigenous in north province of Iran. Other species; Hamamelis virginiana is grown in north• of America and has a little distribution in the Europe. Plentiful investigation was performed on the Hammel& virginiana and species but there is no study about Hamamelis ʹErika and this study is the first report regarding the clinical and phytochenaical study of the plant. Hamamelis persica leaves were collected in May, August and October of 1999 from Mazandaran. Extraction was accomplished fromʹ the leaves through percolation by ethanol 70. Tannins were measured by spectrophotometric method. For-the clinical study as antiperspirant, a roll-on preparation was formulated on the extract by using of glycerol, propylene glycol, water, carbapol 934p, antioxidant and preservative. The dry extract was used in amount of 5% in the preparation( The formulation was prepared in suitable viscosity. The product stability was evaluated during 5 months. Then the product and placebo were given to volunteers. The clinical; study was performed in a blind study by questionnaire. Results showed that the leaves contain mainly pyrogallol group tannins (6.11%). The product had suitable stability in clinical study. Sweating was reduced in 85 percent of the volunteers that used product as roll-on in armpit.