بررسي مقايسه اي اثرات ضد تشنجي عصاره آبي گياه آكليكل كوهي و فنوباربيتال در موش سفيد آزمايشگاهي

A comparative study on the anticonvulsive effects of the aqueous extrract ot the Rosmarinus officinalis plant with phenobarbital in pentylentetrazol-induced seizures in mice

Introduction: The convulsive disorders are among chronic diseases, which usually need a long-term drug therapy. Unfortunately, most of the drugs used clinically to treat disorders exert many side effects. Therefore, search for finding new drugs is being carried out in many laboratories. The object of this research is a comparative study on the anticonvulsive effect of the aqueous extract of the plant Rosmarinus officinalis with phenobarbital in pentyleneterazol-induced seizures in mice. Materials and Methods: After acclimatization, animals were randomly divided in different groups. Control group received normal saline (6 ml/kg), standard groups received (10, 20, 30 and 40 mg/kg) phenobarbital and the test groups received aqueous plant extract (3, 6, 9 and 12 ml/kg). All injections were carried out as i.p. All animals were firstly exposed to pentylentetrazol (80 mg/kg, i.p). The onset of seizures, behavioral changes, duration of the seizures and number of death were recorded in all groups during the first 24 hours. Results: Results showed that all amounts of the plant extracts delay the onset of seizures but the most effective dose was 12 ml/kg, which was comparable to phenobarbital (30 mg/kg). All amount of the extract, except 3 ml/kg, significantly reduced the duration of seizures, compared to the control group. Number of death was 45, 0 and 10 percent in control, standard and test group; respectively. Conclusion: Findings showed that 12 ml/kg of the aqueous plant extract is able to reduce the onset of seizures, duration of seizures and number of death after 24 hours in pentylentetrazol-induced seizures.