برش هاي زنده هيپوكامپ موش هاي صحرايي مستعد به حملات صرع در اثر تزريق مكرر پنتيلن تترازول CA1 تاثير پايداري پالس تتا بر فعاليت عصبي ناحيه

Examination of theta pulse effect on CAl synaptic transmission in hippocampal slices of pentylenetetrazol - kindled rats

Introduction: Effects of theta pulse stimulation (TPS) on CAl synaptic transmission in pentylenetetrazol (PTZ) kindled rats were studied. Materials and Methods: PTZ (45 mg/kg) was injected every 48 hours to NMRJ male rats. Hippocampal slices were prepared from control, partially and fully kindled rats. Theta pulse was delivered to Schaffer collaterals and recording was made from strata radiatum and pyramidale of CAl region of hippocampal slices. Results: PTZ kindling resulted in an enduring increase in fEPSP slope, but not OPS amplitude,in CAl region of hippocampus. TPS decreased the amplitude of population spikes (PS) of partially and fully kindled rats which was significant in the latter as compared to controls. Discussion: It is concluded that repeated administration of PTZ can change susceptibility of CAl synapses to TPS.