جلوگيري از آتروفي عضلاني با تسريع در روند ترميم عصب ضايعه ديده در زبان رت

Prevention of muscular atrophy with accelerated regenerational processing of the injured nerve in ratʹs tongue

Introduction. Previous studies indicated that if regenerational rate in injured peripheral nerves is speeded, a new neuromuscular junction is performed before atrophy in denervated organs. The aim of this study was to examine the effect of fetal brain extract on regeneration of the injured nerve in ratʹs tongue. Materials and Methods. 12 male wistar rats at the age of 2 months were used in this study. The animals were anesthetized and their right hypoglossal nerves transected near the tongue. Rats divided into the experimental and control groups (n=6 in each group). The first group was treated with fetal brain extract (FBE, 0.1 ml) for 20 days (every other day). In the similar condition, the second group was received physiological serum. In the days of 20 and 40 after operation, the animals were anesthetized and perfused and their tongues were removed. Then tongues were processed and microscopic specimes were studied in both experimental and control groups. Results. The data show a significant low atrophy (P<0.05) in denervated side of tongue in experimental group in comparison with control group. Conclusion. FBE can enhance regenerational rate in the injured peripheral nerves and prevent the atrophy in denervated organ.