نقش گيرنده هاي گلوكوكوريتكوييد آميگدال و هيپوكمپ در فرايند ذخيره حافظه در موش بزرگ آزمايشگاهي

The role of hippocampus and amygdala glucocorticoid receptors in modulation of memory storage process in rats

This paper is a summary of our recent findings about the role of hippocampus and basolateral amygdala (BLA) glucocorticoid receptors (GRs) in modulating of memory processes in rats. In all experiments, injections of specific glucocorticoid agonist (dexamethasone) and antagonist (RU 38486) were performed, into BLA and hippocampus. The animals were trained and tested in Passive and Place Avoidance learning and Morris Water Maze models. Results indicated that pre- or post-training injections of specific glucocorticoid receptor agonist or antagonist enhance or impair memory storage, respectively. Retrieval test was not affected by glucocorticoid receptor agonist or antagonoist injection in BLA or hippocampus. These finding indicate that glucocorticoid effects on memory consolidation are mediated in part by activation of GRs in the BLA and hippocamus and are in agreement with this general hypothesis that BLA and hippocampus integrate hormonal and neuromodulatory influences on memory consolidation.