بررسي معيارهاي تشخيص آسپرژيلوزيس برونكوپولمونري آلرژيك در بيماران مبتلا به آسم عودكننده

Diagnosis of allergic bronchopulmonary aspergillosis in asthmatic patients

ntroduction: Allergic bronchopulmonary aspergillosis (ABPA) is an immune disease due to Aspergillus antigens which can cause allergic reactions as well as intensive inflamatory reactions in deep parts of pulmonary system in human. In the present study, 147 patients with asthma that refered to Dr. Shariati hospital and mycology center of the faculty of health in Tehran unversity of medical sciences have been investigated for the probability of ABPA cases. Material and Methods: Patients were examined by physician and after confirmation of asthma, their blood samples were used for staining and WBC counting. Blood sera were also used for estimation of total IgE amount and antibody precipitation tests. Also we evaluated skin prick test to commercial antigen of Aspergillus fumigatus. Sputum samples were used for direct examination and fungal culture methods. Results: ABPA disease found in 6 patients and 3 other patients recognized as allergic asthma due to Aspergillus agents. The whole 4% of the patients indicated as ABPA cases, matched with the area situation in Iran. Conclusion: On the basis of these findings, more investigations for ABPA cases in asthmatic patients are recommended.