اثرات تراتوژنيك استامينوفن بر تكامل سيستم بينايي جنين موش

THE TERATOGENIC EFFECTS OF ACETAMINOPHEN ON DEVELOPING VISUAL SYSTEM IN MOUSE EMBRYOS

Introduction : In the past few decades it has become increasingly evident that human embryos are subject to a variety of environmental influences that might have deleterious effects on their development. One agent to which many human mothers may be exposed is acetaminophen. Acetaminophen is a widely used analgesic and antipyretic which is considered safe at thereapeutic levels during pregnancy. Materials and Methods: In this investigation, we administered therapeutic does of acetaminophen (48.5mg/kg) in mice during critical periods of pregnancy (days 8-11 of gestation). We also administrated the double therapeutic does (97mg/kg) of acetaminophen to other experimental group. The control were received the same volume of physiological serum on the same days. Results: Our finding have shown that the administration of therapeutic doses of acetaminophen resulted in defects of the visual system such as microophthalmia, anophthalmia, intrauterine gross retardation and fetal resorption among other developmentally related malformations are those affecting the centeral nervous system, urinary tract and skeletal system. Although administration of a doubled therapeutic dose caused a further increase in the severity and frequency of the malformations, there was no significant difference in visual system defect in experimental groups. Conclusion: It seems that when pregnant animals were exposed to acetaminophen, it is metabolized in the liver and converted into potentially toxic metabolites. These metabolites can pass through the placenta and may cause malformation in the embryo. The mechanism by which acetaminophen affects components of the developing embryo remains to be determined.