و نتايج بيوپسي آنها به منظور تعيين پارامترهاي سيتولوژيك قابل اعتماد ASCUS بررسي مقايسه اي پاپ اسميرهاي داراي

A COMPARATIVE STUDY OF ATYPICAL SQUAMOUS CELLS OF A COMPARATIVE STUDY OF ATYPICAL SQUAMOUS CELLS OF BIOPSY RESULTS FOR DETERMINATION OF RELIABLE CYTOLOGIC PARAMETERS

Introduction : Microscopic evaluation of cervicovaginal smears(Pap smear)plays an essential role in detection of the preneoplastic and neoplastic lesions of uterine cervix. A wide spectrum of changes are seen in Pap smears. Interpretation of intermediate changes which resulting in observation of so-called ASCUS is difficult. ASCUS is defined as a cellular change that is more marked than typical reactive change but lack features diagnostic of intraepithelial neoplasia. Different studies revealed that in 30%-40% of cases with ASCUS in Pap smear, dysplasia was seen in biopsy sample. The aim of this study was determination of reliable cytologic parameters to identifying real nature of ASCUS. Methods : In this near 4 years investigation, all Pap smears with presence of ASCUS which followed by biopsy samples were reviewed. In this regard 17 parameters of cytoplasm, nuclei and smear background were considered and the datas analysed by SPSS and Chi Square test. Results : After statistical evaluation, we found that 4 parameters of irregular nuclear contour, increased nucleo-cytoplasmic ratio, cytoplasmic vacuolization and dirty background are highly suggestive of dysplasia. Discussion : It is important to consider that to find out the real nature of ASCUS a group of parameters are more helpful than a single one. Also, a single Pap smear is not enough .for this purpose and further investigation is required.