INVIVO مطالعات RAT بررسي ارتباط متابوليسم منگنز و آهن در

INTERRELATION BTWEEN MANGANESE AND IRON METABOLISM IN RAT (IN VIVO STUDIES)

Introduction : Manganese is an essential trace element. There is a little evidence for deficiency of manganese in human. Whereas its toxicity has been reported in several cases. Manganese toxicity occurs in humans exposed to high environmental concentrations (for example workers in the dry battery industries) and may be particularly important in the neonatal period. The chemical similarities between manganese and iron, may lead to the disturbances of iron metabolism. Therefore, the interference of Mn with Fe metabolism by In vivo studies, has been investigated. Methods & Material : In the present project, we used rats. Injection of manganese was carried out by using MnCl2 4H20, with cancentration 100 mg/ml. Seven group of male rats were selected, so thet each group included five rat and manganese injected in their perituneum. Results : The data of this study indicate that factors such as serum iron; TIBC; UIBC and pure transferringe reduced to 9-40 percent, whereas serum managanese significantly elevated. Thus, manganese can interference with iron metabolism. Discussion : The data that has been presented in this article elucidated the probable mechanism by which Mn interference with Fe metabolism; which result in the appearance of anemia.