بررسي مقايسه اي اثر نيفديپين خوراكي و سولفات منيزيم وريدي در پيشگري از زايمان زودرس

EFFICACY OF NIFEDJPINE VERSUS MAGNESIUM SULFATE IN THE MANAGEMENT OF PRETERM LABOR

This study compares the efficacy of nifedipine with magnesium sulfate in arresting preterm labor. Forty sir singleton pregnancies with preterm labor were assigned randomly to either magnesium sulfate intravenously (n=23) or niferdipine prally (n=23). The principal outcome assessed was delay of delivery. Both drugs were equally effective in arresting labor and delaying delivery up to 48 hours (78% versus 91% p =NS) to one week (65% versus 73%, p =NS) and to term (52% versus 61%, p =NS) There were significantly fewer maternal side effects in the nifedipine group (39% versus 74% p = 0.03), and duration of maternal hospitalization in the nifedipine froup was shorter than magnesium sulfate group (2.65 versus 5.7 days , p =0.007) Apgar scores were similar in both groups. the magnesium sulfate (17% versus zero, p = 0.03) These results suggest that oral nifedipine is as effective as magnesium sulfate in arresting preterm labor, and is significantly associated with fewer maternal side effects, and fewer admissions to the NICU.