بررسي اثرات پاتولوژي ناشي از كروم بر روي بافت كبد رت

PATHOLOGICAL EFFECTS OF CHROMIUM ON RAT LIVER TISSUE

Introduction: Chromium is necessary for carbohydrate and lipid metabolism. Chromium (III) is necessary for the activation of Insulin secretion and it is used ,fbr the treatment of NIDDM in very low concentration. It produces toxicity particulary in Nuclear hepatocvtes in high concentration. In this project the acute and chronic effects of chromium on rat liver tissue has been investigated. Methods: Rats were divided into two groups. In one group 2mg/kg chromium were injected daily for 30 and 60 clays and in another group 400 mg/kg of chromium administered for one clay Rat were anesthetized with ether anal their liver were removed for microscopic examinations. Results: results obtained show that intraperitoneal administration of 2mg chromium for 30 clays causes vascular fibrosis (+2) and intermediate fibrosis and inflammation of vascular (+3). Administration of 400 inglkg of chromium causes secretion of lymphocytes and accumulation of neutrophil. Discussion: Chromium is an essential element in low concentration and toxic particularv at very high concentration.