در بيمارستان ميرزا كوچك خان تهران )ICSI(INTRA CYTOPLASMIC SPERM INJECTION بررسي اثر استراديول در فازلونتال روي درصد حاملگي و لانه گزيني در بيماران تحت

EVALUATION OF THE EFFECT OF F2 DURING THW LUTEAL PHASE ON PREGNANCY RATES AND IMPLANTATION RATES IN PATIENTS UNDER GOING ICSI. (INTRA CYTOPLASMIC SPERIN INJECTION)

Introduction: Despite the improvements in assisted reproductive technologies, ART Prosess is with a low successing rate. There are two major determinants of implantation: embryos and the endometrium. Although progesterone secretion is considered the major hormonal event during the luteal phase, E2 appears to play a crucial role as well. Methods: Patients who were undergoing ICSI with controlled ovarian hyperstimulation using a GnRH analog participated in the study. Patients were prospectively randomized into two groups for luteal phase supplementation. Patientʹs in-group I did not receive exgenouse E2 supplementation during the luteal phase. Patientʹs in-group 2 received 2mg of E2 po/bid that starting on day 3 after E. T. serum concentrations of E2 and progesterone were measured in all patients on day HCG injection and on day 12 after E. T. pregnancy and implantation rate were documented. Studentʹs t-test and Fisherʹs exact were used for the statistical analysis of the date. Results: Higher E2 and progesterone levels found during the luteal phase and higher pregnancy rate were recorded in the patients who receive E2 supplementation and were treated with the long GnRH analong protocal. Conclusion (s): The results of this study indicate the patients who are treated with the long GnRH analong protocol for controlled ovarian hyperstimulation, the addition of E2 to the progestin support regime may have a beneficial effect on pregnancy rate.