مطالعه تعدادي از فاكتورهاي بيوشيميايي و هماتولوژيكي در كارگران يك واحد توليدي اكسيد روي مشكوك به افزايش غلظت پلاسمايي روي

STUDY OF SOME BIOCHEMICAL AND HEMATOLOGICAL SERUM PARAMETERS IN SUSPICIOUS INTOXIFIED WORKERS WITH ZINC

Introduction: Zinc is an essential trace element in human. Its major biochemical role being as constituent in a variety of metalloenzyme systems with catalytic functions. Zinc deficiency which causes lesions, alopecia and has linked to growth retardation and mental disturbance is relatively easily treated with zinc supplements. In contrats, serious exposure to zinc oxide may causes zinc toxicity. In this study, some biochemical and hematological serum parameters with are possibly resulted zinc toxicity, were investigated. Materials & Methods: In this study blood samples of 18 normal inviduals and 18 workers which were exposed to ZnO, for at least 10 years were collected and the concentration of zinc and copper were measured by atomic absorption. The coulter counter was used for deteminiation of CBC, Hb and HCT. The amount of iron, TIBC and the all types of lipids were also measured using different kits. Results: The results showed that the mean serum concentration of zinc in workers and healthy volunteers were 144±17,ug/dl and 114±15 ug/dl respectively. Serum levels of iron, TIBC and Hb were reduced by 10.6. 12.7 and I0. Ipercent compare to normal range respectively. These parameters were not significantly different in workers compare to healty volunteers. Changes in copper and lipids were also not significantly different. Discussion: This study showed that in spite of elevation in serum zinc level in workers, other biochemical (serum copper, iron and lipid protein) and hematological (Hb, hematocnit and CBC) parameters have not be affected which might be due to the duration fo the toxicity.