مطالعه اثردرماني كليندامايسين موضعي و مقايسه آن با تتراسايكلين خوراكي در درمان جوش جواني

EVALUATION OF TOPICAL CLINDAMYCIN EFFECT AND COMPARE WITH SYSTEMIC TETRACYCLINE IN TREATMENT OF ACNE VULGARIS

Background & Aim: Acne vulgaris is an inflammatory disease of sebaceous glands. Acne is the most prevalent inflamed skin disease with unknown cause that is characterized by forming comedones, erythematous papules and pustules. Acne prevalence percentage is 30-60% in adolescents. Age peak of acne occurrence for girls is in 14 - 17 years and for boys is in 16-19 years. 15 percent of acne occurs in server form and 85% are physiological acne that remain to second half of third decade of life and gradually are removed. The systemic antibiotic especially tetracycline have used as the selective treatment of acne vulgaris for many years. Long term using of this drug, will cause digestion side effects, however replacement of them with local treating decreases the side effects. Materials & Methods: This study was performed on 100 students of Urmia, in two groups so who were randomized to receive treatment with oral tetracycline (1gr/ per day for 16 weeks) and clindamycin 1% topical solution (16 weeks). Results: the results of this study showed there was no statistically significant difference between effects of oral tetracycline and clindamycin in number of open and closed comedones, papules and pustules (p- 0.6, t= 1.2). The most effect of tetracycline treatment was in 6rh week and clindamycin was in 4th Week (r= 0.71 p = 0.03). Discussion: If further research can obtain the same results, in base of theses findings we can replace treatment of clindamycin (1 %) by systemic treatment of tetracycline, to prevent side effects of long term tetracycline therapy because it have had caused mostly digestion side effects and has some problems to patient. Mean while, because of easy using of local treatment, it is more acceptable for the patient.