Balb/c بر فعاليت هاي حركتي و تعادلي موش نژاد )HYoscyamus niger( تاثير تزريق پيش از تولد عصاره الكلي گياه بنگ دانه

EFFECT OF PRENATAL ADMINISTRATION (IP) OF HYOSCYAMUS NIGER ALCOHOL EXTRACT ON MOTOR ACTIVITY AND BALANCE CONTROL OF BALB/C MICE

Background & Aim: The development of nervous system during embryonic period is sensitive to the presence of exogenous agents like herbal extracts. Hyoscyamus tiger, which have been used in traditional medicine in different disorders like nervous diseases, contains anticholinergic alkaloids. The aim of this study is to find out the effects of prenatal exposure of the alcohol extract of leaf of this plant on balance control and motor activity in inbred mice. Materials and Methods: In this study, the herbal extract was injected to Balb/C mice during 6-8 embryonic days (neurolation period) intraperitoneally. One month after birth, by using Rota-Rod apparatus and activity monitoring system, the time of balance control and motor activity were recorded. Results: The results showed that in treated mice, the time of balance control, ambulatory, stereotypic activities and distance traveled were decreased but the resting time was increased. Discussion: Therefore, it seems that this herbal extract exerts its permanent effects on the balance and motors systems due to the presence of its anticholinergic agents. In spite of using this plant for treating some disorders, it should be used with care during pregnancy.