مقايسه اثر كاپتوپريل خوراكي و نيترات زيرزباني در كنترل حملات پرفشاري خون

Comparing oral captopril and sublingual nitrates in controlling urgent hypertension crisis

Introduction: Hypertension crisis is one of the most common reasons of the patientʹs reference to emergency units. Many intravenous and oral drugs are available for controlling hypertension crisis. Intravenous nitrates are one of these drugs but there are few studies regarding the effect of oral nitrates on hypertension crisis. This study compares the effect of oral captopril and sublingual isosorhide dinitrate in controlling urgent hypertension crisis. Methods: In this double blind clinical trial 100 patients with urgent hypertension crisis (BP> 18011 10) without end organ damage took part. Fifty patients received 10 mg of sublingual isosorhide dinitrate and fifty others received 50 mg of captopril. The blood pressure of the patients was measured every ten minutes up to 90 and 60 minutes in captopril and isosorhide group respectively. The data were analyzed using T test and ANOVA. Results: The patients were between 24-75 years old. In captopril group blood pressure decreased from 194±9 mm11g/115±2 mml/g to 152±7/86±2 and in isosrhide group from 198±10 mmHg/112±4 mm}lg to 155±8 mmHg/81±3 mtnl/g. There was a 20.9% decrease in blood pressure in captopril group and a 21.63% decrease in isosrhide group. T test and ANOVA showed no significant difference between the two groups in reducing blood pressure. Conclusion: This study indicated that 10 mg sublingual dinitrate is at least as effective as 50 mg captopril in controlling urgent hypertension crisis.