عنوان مقاله :
اينديوم بليومايسين [111Ln] تهيه راديوداروي
عنوان به زبان ديگر :
Preparation of [111 In]-Bleomycin radiopharmaceutical
پديد آورندگان :
اميررضا جليليان ، مترجم ,
كليدواژه :
Fibrosarcoma , كمپلكس راديودارو , اينديوم - 111 , بليومايسين , سلول سرطاني , پزشكي هسته اي , تومور بافت همبند , موش , Radiopharmaceutical , In-111 , bleomycin
چكيده لاتين :
In this study, the preparation of "In-Bleomycin complex was optimized for temperature, time, concentration and pH during several experiments. The results showed that by the addition of Bleomycin to111In-InCl3 sample (dried under flow of N2) and heating the mixture up to 90-100`C the radiopharmaceutical can be obtained in 99.5% yield and a specific activity of 1.745 Ci/mmol. The final sample was injected into fibrosarcoma-bearing mice via their tail vein. Satisfactory preliminary SPECT images were acquired between 2-4 hours post-injection showing suitable accumulation in fibrosarcoma tumors.
كلمات كليدي :
#تست#آزمون###امتحان
