ترميم انتها به كنار عصب (مطالعه تجربي در خرگوش ها)

End-To-Side Neurorrhaphy: An Experimental Study in Rabbits

Background: The concept of end-to-side nerve repair was recently introduced; however, most authors have reported conflicting results with this technique. This study was conducted to assess the effectiveness of end-toside nerve repair in both fresh and predegenerated specimens by histological evaluation in an animal study in rabbits. Materials & Methods: Thirty male rabbits were divided into three groups. In group 1 (14 animals) fresh end to side anastomoses was done between the divided peroneal nerves and tibial nerves via an epineural windows. In group 2 (13 animals), the peroneal nerve was divided and sutured end-to-side to the tibial nerve after a 1-week "predegeneration period". In group 3 (N=3), which was considered the control group, the peroneal nerve was divided and sutured to the adjacent soft tissues. After 3 months, specimens were harvested for histological evaluation. Results: Nerve fiber count, in normal peroneal nerves, averaged 532/cross section. In groups I and 2 average nerve fiber count in implanted peroneal nerves was 6.24 and 7.00/cross section, respectively. No significant difference was observed between fresh and "predegenerated" groups (p=0.9). Conclusion: These data suggest that collateral sprouting of donor nerves is possible after end-to-side Neurorrhaphy through an epineurial window, but the number of nerve fibers in recipient nerves is too low to result in any functional recovery in the target organ.