در نوزادان ABO بيماري هموليتيك ناشي از ناسازگاري گروههاي خوني

ABO-Hemolytic disease of the Newborn

ABO Hemolytic disease of the newborn is the most common cause of Hemolytic jaundice in newboms. In a prospective study during 1997,we determined the clinical course and incidence of hemolytic disease of newborn due to ABO blood group incompatibility in Ghaem Hospital. In the present study from a sample of 128 blood group (0) mothers, 50 term neonate, had blood group A & B as case group, and 50 neonates without incompatibility considered as control group these infants were compared for hyperbilirubinemia in first 3 days of life. Skin Bilirubin index, measured daily in both groups of newboms byjaundicemeter instrument. In babies with critical index (skin Bilirubin > 17) serum bilirubin and other Hematological values were determined. In this study, six newboms had significant jaundice (Bilirubin>15mg/dl) in incompatible group but in control group only 2 infant had hyperbilirubinemia in first three day of life. Taking into account that in Mashhad their frequency & blood o is nearly 60%, it was concluded that in general population of pregnant mothers 24%, Present feto- maternal ABO incompatibility. This figure is less than value that reported by others, therefore, incidence of ABO- Hemolytic disease in all of newboms is 2/9 percent (%24).