يافته هاي آزمايشگاهي در پيوند موفق و رد پيوند كليه

Labratory Findings in The Children With Diarrhea in Mashhad,1999-2000

Renal transplantation has now become a preferred treatment modality for patients with end stage renal disease. Accurate recognition and treatment of rejection is major concern in the early post transplant period. This study is carried out to evaluate success of transplantation based on some laboratory findings. The results show that creatinine in both groups were meaningfully decreased 48 hours after transplantation (P<0.006). However average serum concentration of creatinine 48 hours after transplantation in the rejected group compared with the group with successful transplant was higher from a statistical viewpoint (P<0.04). Uric acid evaluation in both groups showed that the uric acid level difference before transplantation and 48 hours after transplantation was not meaningful. It was interesting that in the successful transplant group, the serum uric acid level showed considerable statistical decrease 48 hours after operation (P<0.0001) in comparison with preoperative level. In this study, the result related to BUN showed a pattern like uric acid. Although in the case of BUN there was considerable decrease 48 hours after transplantation in the successful group (P<0.0001). The average amount of serum BUN 48 hours after transplantation in the rejected group was considerably more than the successful transplant group (P<0.001). No meaningful difference was observed in the total Count of WBC between two groups. Interestingly, it was observed that the total number of leukocyte was not influenced by rejection while the percentage of neutrophil and the total number of neutrophils in mm3 of blood were influenced by rejection. On the other hand, we know that transplant rejection is an immunological activity and it is expected that the number and percentage of lymphocytes in circulation during transplant rejection to be increased. However surprisingly, in the rejected group, there was a meaningful decrease (P<0.006) in lympho-cyte count 48 hours after transplantation. This may be because of the immunologically suppressive drugs. About monocytes, the number and percentage were not influenced by graft rejection.