تعيين ارتباط عفونت هليكوباكتر پيلوري با بيماريهاي عروق كرونر

Association Between Helicobacter Pylori Infection and Coronary Heart Disease

Cardiovascular diseases are one of the most causes of morbidity and mortality in industrial and developing countries such as Iran. Different studies have been done to find out whether or not Helicobacter Pylori(HP) is a risk factor for cardiovascular diseases, but different results have been obtained. HP infection is common in our country too. In this analytic cross-sectional study, which was conducted on 261 patients, 131 hospitalized patients were selected from CCU ward as cases and 130 hospitalized patients from surgery and orthopedic wards of Iran University of Medical Sciences hospitals as controls. HP infection was determined according to IgG titer using ELIZA method. T-test, chi-square and general linear model were used for the analysis of the data. Sex and job were the same in both groups. Cases had higher age and weight(P<0.001) and lower knowledge(P=0.002) than controls. Smoking and hypertension was more in cases too(P<0.001). Patients with HP infection were 56.3% in cases and 43.8% in controls. These differences were not significant even after controlling age, weight and coronary heart diseases(CHD). Risk factors of CHD had significant correlation with HP infection(P=0.022, r=0.171). In conclusion, previous infection with HP is not a major risk factor for CHD.