سرم افراد بالغ مبتلا به سينوزيت مزمن تحت عمل جراحي IGE در مخاط سينوس و ميزان CD/4CD8 و نسبت CD8 و CD4 ، CD3 شمارش

Lymphocyte Subsets (CD3, CʹD4, CD8), CD4/CD8 Ratio of Sinus Mucosa and MeasureiSerum IgE Lever in Adults with Chronic Sinusitis Undergoing Surgery

This study was conducted to investigate the role of cell immunity in adults suffering from chronic sinusitis who referred to Rasoul-e-Akram Hospital for endoscopic sinus surgery. CD3, CD4, CD8 & CD4/CD8 ratio in sinus mucosa of serum IgE level were all measured in the patients. The three studied groups were: chronic sinusitis with high serum IgE(28 cases), chronic sinusitis with normal range serum IgE(45 cases) and a control group with no sinusitis and normal serum IgE(10 cases). It was found out that chronic sinusitis occurred more often in persons with high serum IgE than normal range serum IgE(P=0.012). Females with serum IgE more than 100IU/ml, had a higher risk for chronic sinusitis compared to males(P=0.05, OR=2.8). CD3, CD4, CD8 counts and CD4/CD8 ratio had no correlation with age and serum IgE. CD4 to CD8 ratio in different anatomical regions of mucosa showed that CD4/CD8 in nasal cavity was greater than ethmoid sinus(2.6vs 1.9) and it was greater in ethmoid sinus than in maxillary sinus(1.9vs 0.9). Also, more CD8 lymphocytes were seen in maxillary sinus mucosa than ethmoid sinus mucosa and nasal cavity, but statistically there were no significant differences between these anatomical regions. CD3 cells in nasal cavity and CD4 cells in ethmoid sinus were greater than other regions. Number of CD4 cells were significantly higher in patients with nasal polyp than in others(P=0.002). Due to several affecting factors in cellular immunity in sinus mucosa, it is necessary to perform more detailed studies in this regard.