بررسي پتانسيل نيوپلازي خال سباسه

Neoplastic Potential of Sebaceous Nevus(Clinico- Histopathotogical Study)

Sebaceous Nevus of Jadassohn is a hamartoma that is a combination of epidermal, follicular, sebaceous and apocrine gland abnormalities. Classically, several types of malignant and benign cutaneous neoplasms have been associated with this hamartoma. Due to the absence of a complete study in Iran for analysis of sebaceous Nevus(SN) incidence, its associated malignancy and developmental defects, we retrospectively studied a series of 42 cases of sebaceous nevus with clinicopathologic correlation over a 10-year period in Hazrat Fatemeh Hospital. The goal of this study was to detect the correlation between sebaceous nevus and cutaneous neoplasms. Several histopathologic changes related to the age of the patients were found. Most of the patients were over 18 years old(63.2%) and the scalp was the most common location of SN(52.4%). Three cases(7.15%) of basal cell carcinoma and three benign cutaneous tumors(leccrine spiroadenoma(2.4%), 1 trichoepithelioma(2.4%) and 1 inverted keratoacanthoma(2.4%)) arising out of previous SN were found. On the basis of these findings, prophylactic treatment which consists of early excision for preventing the development of the malignancy is recommended for this hamartoma.