بررسي عواقب دراز مدت و فاكتورهاي پيش بيني كننده درگيري ارگان ها در اسكلروزسيستميك

LONG TERM OUTCOME AND PREDICTIVE FACTORS OF ORGAN INVOLVEMENT IN SYSTEMIC SCLEROSIS

This study is done to compare the long term outcome in two group of patient withsystemic sclerosis(SSc), diffuse cutaneous type(dcSSc) versus limited type(lcSSc) and determine predictive factors for specific organ involvement. Patient had to meet American College of Rheumathology(ACR) criteria for clacification of SSC eligible to study. In this study only clinically detectable antemortem evidence of organ system involvement attributable to SSc was considered. Two groups compared with regard global and local outcome and any organ system involvement and survival rate. Predictive factors for any organ system involvement analyzed. Group means were compare using 2-Tailed T-test. Dictomous variable analyzed by using chi-square test. Logestic regretion for prediction of factors on any organ involvement. Life table method was used for survival study. 38 patient entered the study. 9 patients with dcSSc and 29 patient with lcSSc type. Mean age of patient in two groups was 40.8 year. Sex ratio(F/M) was 8:1. Mean duration of disease from first symptom onset was 8.3 year for two groups. There was no difference in long term study in 6 organ system involvement, or local and global outcome variables. Survival was not significantly different(P>0.05). There was no predictive role for any variable to specific organ involvement by logestic regretion(P>0.05). No difference in long term between outcome variables and survival. No predictive factor for organ system involvement was found.