بررسي تاثير امپرازول و سيپروفلوكساسين در درمان زخم اثني عشر و ريشه كني عليكوباكتري پيلوري

EFFECT OF OMEPRAZOLE PLUS CIPROFLOXACIN ON HEALING OF DUODENAL ULCER AND ERADICATION OF HELICOBACTER PYLORI

Recently the combined therapy of Omeprazole (0), a powerful anti-ulcer drug with antibiotic has been studied in patients with helicobacter pyloi (HP) associated duodenal ulcer (Du). The efficacy of (0) plus Ciprofloxacin (C) therapy on healing of Du and eradication of HP was tested in a randomized, double-blind, placebo controlled prospective study. Eighty four patients with HP positive Du disease were randomly assigned to receive (0) 20 mg daily (28 days) plus (C) 250 mg bid (7 days) or placebo. The patients were devided in to the following four groups. Group 1 (0+C: N=22) Group 2 (0 placebo +C placebo: N=22) Group 3 (0 placebo +C: N=19) Group 4 (0+C placebo: N=21) Endoscopy and two biopsy samples from antrum for rapid urease test and histology were performed in all patients at the entry and three to seven days after the completion of the therapy. The healing rate was 88% in group 1, 13% in group 2, 24% in group 3 and 78% in group 4. The proportions of Hp negativity were 65% in group 1, 13% in group 2, 19% in group 3 and 24% in group 4. The highest rate of ulcer healing or Hp eradication was observed in group 1 receiving "O+C". Conclusions: 1- Omeprazole is a safe and effective drug for short term ulcer therapy in patients with Du disease. 2- Omeprazole plus Ciprofloxacin therapy is highly effective concerning Hp eradication. 3- Du healing rate with (0) plus (C) Therapy may be increased as compared to Omeprazole therapy alone.