بررسي فراواني نارسايي حاد كليه در نوزادان مبتلا به سپتي سمي در بخش نوزادان بيمارستان بهارلو(سالهاي 1378-1377)

THE ASSESSMENT OF ACUTE RENAL FAILURE FREQUENCY DURING NEONATAL SEPSIS AMONG NEONATES ADMITTED TO NEONATAL WARD OF BAHARLOO HOSPITAL(1998-1999)

Neonatal sepsis is common specially in developing countries and is the main cause of neonatal mortality. Among the organs which are influenced during sepsis kidney is associated with mortality rate.This study was undertaken to determine the association between acute renal and sex, age, birth weight, type of treatment, gestational age, duration of treatment and the history of asphyxia. In this cross-sectional descriptive and analytical study the information of neonates who had been admitted to Baharloo Hospital between 1998 and 1999 was registered on questionnaires and then analyzed. Among 500 studied neonates, 320 had inclusive criteria. Based on two standard deviation increase in creatinine level, which is higher than blood creatinine level adjusted to age, 72 neonates were considered to have acute renal failure(22.5%). The males were 55.5% and females were 44.5%. The mean age of the population was 8.4 days and the mean age of acute renal failure cases was 11.6 days. The mean duration of the treatment of acute renal failure group was 6.2 days. The mean birth weight of the population was 2813 grams. Only 20% of neonates with the history of asphyxia were affected with acute renal failure during sepsis. The two groups were treated with nephrotoxic drugs. In this study the association between gestational age, sex, birth weight, history of asphyxia, nephrotoxic drugs and acute renal failure was not significant, whereas the association between neonate age, duration of treatment and acute renal failure was significant. Theretbre, it is recommended that the duration of the treatment should not be prolonged and renal function should closely he monitored in septic premature neonates.