مطالعه سيستم عصبي اتونوم در بيماري اريترو ملالجيا

SYMPATHETIC SKIN RESPONSE IN ERYTHROMELALGIA DISEASE

Erythromelalgia or erythermalgia (EM) disease is characterized by severe pain associated with local warm redness_in the extremities. The application of cold or elevation of the extremity will have the opposite effect of decreasing the pain. Because of this characteristic clinical feature, a local disturbance of vasomotor regulation has been hypothesized asuthe pathogenetic factor in primary EM. Therefore, evaluation of sympathetic nervous system seems to be a clue for elucidating cause of these complaints. sympathetic skin response (S.S.R) is a simpl.:. electrodiagnostic test for evaluation of svmp.atpet;e: sudomotor activity, to this study, the test was performed for lower limbs of 22 patients with diagnosis of primary EM with no history of any other systemic disease or consumption of sympathomimetic or sympatholytic and antihypertensive drugs. Results of this group was compared with the results of 22 healthy subjects with no history of any systemic disease or drug consumption. There is a significant difference between the two groups as well as distal latencies and amplitudes. With at least 2 abnormal criteria from 4 measured criteria,* more than 72% of the patients had abnormal S.S.R. Therefore, involvement of sympathetic nervous system (efferent, c fibers) in primary EM is highly suspected.