) KATP(ATP اثر محافظتي كاپتوپريل در ضايعات كليوي متعاقب ايسكمي و برقراري مجدد جريان خون و نقش كانال هاي پتاسيمي وابسته به

THE PROTECTIVE ROLE OF CAPTOPRIL IN RENAL DAMAGE AFTER RENAL ISCHEMIA AND REPERFUSION AND ROLE OF ATP DEPENDENT POTASSIUM CHANNELS (KATP)

Background: Renal damage after renal Ischemia and reperfusion has been studied frequently and it is known that e ACE inhibitors have a pronounced effect on its prevention. Ito there are many reports about the effect of KATP *channels on heart ischemia and reperfusion to the heart. In regard to above research, in this study the effect of blockers on potassium channels related to ATP was compared to the effect of captopril in kidneys which were ischemic and then reperfused were studied. Methods: In this study, Glibenclaimide (1,5,25 mg/kg) Captopril (5mg/kg) were administred to rats. Then sthesized with ketamin (50 mg/kg) and xylocaine (I Om eir flanks were opened. The left renal vein was obstruc for 30 minutes, then opened for 2 hours, afterward, the rats were killed and their left and right kidney were studied microscopically. Results: The results showed that captopril can decrease emia damage, but Glibenclamide had not such effect. Conclusion: The effect of captopril is not related to KATP els and is probably due to oxygen free radicals and otein kinase C.