تاثير پاتولوژيك بخار فرمالدهيد بر مخاط تنفسي ناي موش صحرايي

Effects of formaldehyde exposure on rats, tracheal mucous membrane - A histopathologic study

background: Formaldehyde is a chemical, which is used traditionally for fixing the cadaver. It is vaporized during dissection and practical studying on cadaver. Studies show that this vapour can cause clinical sympotms such as throat, eye, skin and nasal irritation and tears. This study was designed to determine the histopathological changes of ratʹs tracheal mucous membrane that were exposed to formaldehyde for 18 weeks. Methods: This study was performed on 28, 6-7 weeks postnatal albino Wistar rats. The rats were divided into 3 case groups (El: 4h/d, 4d/w; E,: 2h/d, 4d/w; E3: 2h/d, 2d/w) and I control group. The tracheal specimens were sectioned and stained with H&E technique for histopathological study. Results: An epithelial disorganization, cillia disappearance, slight displastic changes and slight subepithelial lymphocytic infiltration were observed in the case of El. Epithelial disorganization, irregular cilia and slight subepithelial infiltration were seen in E. and E3 groups. Conclusion: The results of this study show that "the more exposure to formaldelhyde vapour, the more intense epithelial changes".