شماره ركورد :
164857
عنوان مقاله :
BALB/C رابطه هيپوتيروييدي مادري و كاهش خارهاي دندريتي در ياخته هاي پيراميدال مغز موش
عنوان به زبان ديگر :
The Relation of Maternal Hypothyroidism and Dendritic Spines Reduction in Brain Pyramidal Cells of Balb/C Mice
اطلاعات موجودي :
فصلنامه سال 1383
رتبه نشريه :
علمي پژوهشي
تعداد صفحه :
8
از صفحه :
172
تا صفحه :
179
كليدواژه :
پزشكي , خارهاي دندريتي , رابطه هيپوتيروييدي , ياخته هاي پيراميدال , Maternal hypothyroidism , Synaptogenesis , Pyramidal cells , Dendritic spines
چكيده لاتين :
Background: Thyroid hormones are well known to be essential for normal development of the brain in human and animals. In particular, thyroid deficiency during the prenatal periods causes significant impairments of structural development and organization of the brain. Therefore in this study, the effects of maternal hypothyroidism on morphometrical changes of synaptic sites of pyramidal cells in the mouse brain was evaluated. Materials and Methods: This study was carried out on 24 balb/c mice. The animals were divided into two experimental and control groups. The experimental group was made hypothyroid by chemical thyroidectomy with oral propylthyouracil (PTU) in drinking water, while the control group was kept intact. On the 20th postnatal day, by using histological technique preparation and histochemical staining (Golgy) method, we were able to investigate the effects of maternal thyroid hormones deficiency, on the development of pyramidal synaptogenesis in postnatal period of the mouse. Results: Our findings showed that maternal hypothyroidism during pregnancy cansed a significant decrease of the dendritic spines in the experimental group (31.08±0.45) compared with the control group (39.88±0.55), (p<0.05). In addition, an increase gap among the synaptic sites of pyramidal cells in the brain cortex among the experimental group (3.78±0.86) in contrast with the controls (2.57±1.05) were observed (p<0.005). Conclusion: The results of this study indicated that there is a key role for thyroid hormones in connection with maturation and neuronal development of brain cortex. Also hormonal reduction during pregnancy can affect the development and neuronal synaptogenesis of the next generation.
سال انتشار :
1383
عنوان نشريه :
مجله دانشگاه علوم پزشكي رفسنجان
عنوان نشريه :
مجله دانشگاه علوم پزشكي رفسنجان
اطلاعات موجودي :
فصلنامه با شماره پیاپی سال 1383
كلمات كليدي :
#تست#آزمون###امتحان
لينک به اين مدرک :
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