در بيماران هموفيلي شهر سنندج )TEA( Tranexamic Acid بررسي تاثير مصرف

An Evaluation of The Effectiveness of Tranexamic Acid (TEA) in Hemophilia Patients in Sanandaj

Introduction: Hemophilia is one of the most important coagulation disorders. At the present time the current treatment is factor replacement which may lead to many socio-economic problems and also transmission of some viral infections. In this study we evaluate an alternative treatment to factor replacement to decrease the aforementioned problems. Material and Methods: This was an interventional study and the statistical population included all Hemophilia patients that referred to Besat Hospital. They were randomly divided into two groups: an intervention group of 13 patients and a control group of 15 patients. Tranexamic acid was only used for the intervention group (15 patients). Then the data was assessed by spss win software. Results: In the intervention group bleeding episodes were reduced significantly (from 4.07 episodes per month to 3 episodes per month) and so was the need for factor replacement (from 80.1 u/kg/m to 58.7 u/kg/m). In the control group bleeding episodes and the need for factor replacement did not differ prior to and during the study. Conclusion: The results of this study showed that daily prophylactic use of TEA is effective in reducing bleeding episodes and decreasing the need for factor replacement in hemophilia patients. However, due to increased PTT and decreased serum clotting factors in patients, the risk of life threatening bleeding is likely to be high. Thus we don’t recommend the use of TEA as a prophylactic measure in hemophilia.