تفاوت جنسي روند ايجاد هيپرآلرژي در درد ناشي از گره زدن عصب سياتيك در موشهاي سوري

Gender differences in hyperalgesia process due to partial nerve ligation (PSNL) in mice

Neuropathic pain is a chronic pain which is produced as a result of peripheral nerve damage and causes hyperalgesia (increased sensitivity to noxious stimuli).Gender differences to neuropathic pain have been reported in animal models but the results are controversial. So in this study the gender differences to noxious stimuli and hyperalgesia process are studied in mice using Partial Sciatic Nerve ligation (PSNL) model during 20 days. The response to painful stimulus is tested by Hot plate method in 3 groups of intact, sham- operated and PSNL male and female mice and the reaction time was recorded in intact group. In sham- operated and PSNL groups the reaction time to thermal stimulus was also recorded every other day from 6 to 20 days alter operation. The results of this study showed that the mean reaction time to thermal stimuli was not significantly different between intact and sham- operated mice. But in PSNL mice the mean reaction time decreased significantly in comparison with intact and sham- operated groups.lʹhe mean reaction time to thermal stimuli in PSNL female mice was significantly different from sham- operated groups in 10 th and 14 th days after operation. while in male PSNL mice the reaction time was significantly different in 10th day after operation. I-lyperalgesia iii female mice was continued from 10 to 14 days after operation but in male PSNL mice the hyperalgesia was only observed on I Oth day after operation. In summary the results of this study showed that the partial sciatic nerve ligation caused hyperalgesia in both sexes but the female mice are better models For studying hyperalgesia process. The reason for gender differnce to neuropathic pain following partial sciatic nerve ligation is not determined yet.