كليدواژه :
زنجبيل , تراتوژنيسيته , گياهان دارويي , پزشكي , داروسازي , mice , Zingiber officinale , Teratogenic effects
چكيده لاتين :
Ginger is the root part of Zingiber officinale that contains numerous ingredients including oleoresins, zingiberen, graniol, gingerol, pyrogalols, and hydroxyalkanone. It has been reported that hydroxyalkanone is responsible for the antinausea and antivomiting effect of ginger. In this study, the embryotoxicity effect of aqueous and ethanolic extracts of ginger was evaluated, applying the standard GLP protocol for this purpose. Maximum tolerated dose of the two extracts were determined and appropriate doses were administered intraperitoneumaly in time-pregnant mice on days six to fourteen of gestation. Embryos were harvested by caesarian section on day 18, examined externally and then stained by a microwave technique. Both extracts caused significant retardation in the weight gain of the pregnant mice and a notable reduction in uterus weight. Weight and crown-lump length of treated embryos were reduced. Both extracts caused many skeletal and tissue malformations, which clearly indicated the teratogenic potential of ginger extracts at administered doses. It is suggested that gingerʹs reported effects on smooth muscle, leukotriens and prostaglandins synthesis could be a major factor in producing these toxicities. This plant is used extensively in traditional medicine and based on this study, its use during pregnancy should be restricted until further investigations.
