بررسي اثرات عصاره برگ نوروزك بر روي آنزيمهاي كبدي موش

Effect of Salvia leriifolia leaves extract on liver transaminases in mice

In this study, the effect of Salvia leriifolia leaves extract on liver transaminases was evaluated in mice. Dry powdered leaves were macerated in 80% ethanol for 2 days. The maximum tolerated dose of extract was 1500 mg/kg via intraperitoneal injection. The level of blood enzyme SGOT and SGPT of mice was measured as an index of hepatotoxicity. The high doses of the extracts (200, 900, 1200 and 1500 mg/kg) induced hepatotoxicity but the low dose of the plant extracts (50 and 100 mg/kg) did not induced any significant effect on the isoenzymes. The lower doses did not show any hepatoprotective effect against carbon tetrachloride (25 (mio)l/kg) and acetaminophen (500 mg/kg) hepatotoxicity. The present results indicated that the macerated ethanolic extract of S. leriifolia leaves extract did not have hepatoprotective effects and in high doses itself induced heptotoxicity.