متاآناليز كارآزماييهاي باليني مطالعات اثر سير بر كاهش كلسترول خون با فرض همگني واريانسهاي اثر تيما

Meta-analysis of clinical trials of cholesterol reduction effect of garlic studies with Homogeneity of variances of treatment effects

In order to evaluate effect of garlic on total cholesterol level in patients with hypercholesterolemia. Results of similar clinical trials are composed to gain more precise result and conclusion. This procedure is called meta-analysis. There are several statistical procedures to compose similar studies which in all of them the primary data is not required. The procedure employed in this study is meta-analysis with homogeneity of variances of treatment effects. Six homogenous studies were found among twelve published studies. After synthesis of results, effect of garlic on reduction level of cholesterol is estimated 18.0 (mg/dl) with a confidence interval (10.03, 25.0) which shows significant difference between treatment group (garlic consumption) and control group (placebo). The confidence interval computed for decline in total cholesterol level after garlic consumption is narrower than the other Cis computed in individual studies. simulation was performed to produce artificial data for comparing two method of meta-analysis applied in this research ,new proposed method was better than the common procedure especially when sample sizes of individual studies is small.