بررسي ارتباط كم كاري تيروييد با بالا بودن چربيهاي خون در مراجعه كنندگان به آزمايشگاههاي دانشگاهي در مشهد

Thyroid dysfunction and hypercholesterolemia (HC) in patients referred for dyslipidemia in Mashhad

Hypercholesterolemia is one of the major risk factors for Cronary Heart Disease (CI ID). Plasma cholesterol concentration is increased in hypothyroidism, which can be reduced to normal by L-thyroxine treatment. In this study, 1905 out of 5165 male and female subjects who were checked up for plasma lipids were found to be with high plasma cholesterol and I or triglycerid: From these, 100 subjects were selected for further investigation. Serum lipids were measured by enzymatic methods and TSH and thyroid hormones were measured by routine R1A laboratory technics. Results: Out of 100 hyperchlosterolemic and 1 or hypercholesterolemic + hypertriglyceridemic subjects, 17 were biochemically hypothyroid and 83 were euthyroid. The correlation between high plasma TSH and FTC (r=+ 0.63, P<0.0005) and between TSH and hypertriglycridemia (HT) (r=+ 0.59, P<0.0005) were statistically significant. The correlation between low plasma TT4 with I-IC and FIT also was significant (r=- 0.79, P<0.0005 and r=-0.39, P<0.0005 respectively). Decrease in TT3 concentration and I-IC (r=-0.78, P<0.0005) as well as TT3 concentration and HT (r=-0.45, P<0.0005) were also significant. In hypothyroid group, the correlation between high plasma TSH with HC and also Hʹ1ʹ were significant. The correlation between low TT4 with HC and HT was also significant. The correlation between low TT3 with HC and HT also was statistically significant. The increase in plasma TSH or decrease in TT4 and/or TT3 also was quantitatively correlated with HC and with I-IT.