(مطالعه قند و ليپيد تهران ) HYPERTRIGLYCEMIC WAIST شيوع عوامل خطرساز قلبي - عروقي در مردان

Incidence of cardiovascular risk factors in hypertriglycemic-waist males (Tehran Lipid and Glucose Study)

Introduction: Many studies performed on non-traditional risk factors have proposed a metabolic triad including Increased serum level of apolipoprotein B, hyperinsulinemla and high small dense LDL.C as a risk factor of cardiovascular disease. Hypertriglycemic waist (increased waist circumference as well as high fasting triglycerides) can be used as a simple criterion to predict metabolic triad. The aim of this study was to investigate the prevalence of hypertrlglycemic waist and the frequency of cardiovascular risk factors In the affected population Material and Methods: The study was performed on 18-70 year-old males of the population of Tehran Lipids and Glucose Study (TLGS). The subjects fell Into four groups with respect to serum level of fasting triglycerides (Tg) and waist circumference (W). Subjects of TgHWH group had serum Tg >160 mg/dli as well as WC >95 cm while those of TgHWL group had Tg>160 mg/di and W<95 cm. Triglycerldes level was less than 160 mg/dl in TgLWH and TgLWL groups whereas waist circumference was higher than 95 cm in TgLWH and lower than 95 cm in TgLWL. Cardiovascular risk factors, anthropometric and laboratory variables were compared between groups. Results: A total of 4169 subjects were enrolled of whom 784 had high serum levels of triglycerides as well as Increased waist circumference. The prevalence of cardiovascular risk factors was significantly highest In TgHWH group. Mean age of subjects was significantly higher In TgHWH compared to others (37±15, 48±14, 41+13 and 46±13 years In TgLWL, TgLWH, TgHWL and TgHWH, respectively, p<0.001). Systolic and diastolic blood pressures and body mass Index were significantly higher in TgHWH than others. Serum total cholesterol, trlglycerides and LDL-C were significantly higher in TgHWH compared to others whereas HDL-C was significantly lower in this group. The prevalence of subjects who had at least four risk factors was 75% and 10% In TgHWH and TgLWH, respectively. Conclusion: Hypertrlglycemlc waist can be used as a simple criterion to predict cardiovascular risk factors.