اثر هيپوليپيدميك عصاره آبي برگ شنبليله در موش صحرايي ديابتي

Hypolipidemic effect of aqueous leaf extract of Trigonella foenum-graecum in diabetic rats

Introduction: Considering the hypoglycemic and hypolipidemic effect of the fenugreek seed and hypoglycemic effect of its leaf, this study was conducted to evaluate the hypolipidemic effect of Its aqueous leaf extract. Materials and Methods: Male Wistar rats were divided into control, extract-treated control, diabetic, and extract-treated diabetic groups. Fenugreek extract was administered at doses of 100 and/or 200 mg/Kg (i.p) every other day three days after the induction of diabetes for a period of 2 months. Serum total cholesterol, triglyceride, LDL- and HDL-cholesterol levels were measured one week before the study and again 4 and 8 weeks after the experiment. Results: Serum total cholesterol significantly increased (p<0.05) in diabetic rats, with the extract treatment having no effect in this respect; there was a non-significant Increase In triglyceride levels in diabetic rats again with no effect of extract treatment. On the other hand, LDL- and HDL cholesterol levels significantly increased (p<0.01) and decreased (p<0.05) in diabetic rats respectively, and administration of the extract significantly (p<0.05 and p<0.01) reversed these changes. Conclusion,: The results showed that treatment of diabetic rats with aqueous extract of fenugreek could improve the inappropriate changes in LDL- and HDL-cholesterol and this could reduce the ensuing cardiovascular complications caused by diabetes mellitus.